186 pilotes évolueront sur les 13, 626 km du circuit des 24 Heures. Parmi eux, 6 femmes (Lilou Wadoux, Sophia Floersch, Rahel Frey, Michelle Gatling, Sarah Bovy et Katherine Legge), un octuple champion du monde des rallyes (Sébastien Ogier), un célèbre acteur (Michael Fassbender), de multiples vainqueurs des 24 Heures du Mans (Sébastien Buemi, ...) ou encore d'anciens pilotes de Formule 1 (Giancarlo Fisichella, Esteban Gutierrez, Robert Kubica, Sébastien Bourdais...).
| PROVISIONAL ENTRY LIST : 28.04.2022 | ||||||
| N° | HYPERCAR | NAT | CAR | Driver #1 | Driver #2 | Driver #3 |
| 7 | TOYOTA GAZOO RACING | JPN | Toyota GR010 - Hybrid | Mike Conway (GBR) | Kamui Kobayashi (JPN) | Jose Maria Lopez (ARG) |
| 8 | TOYOTA GAZOO RACING | JPN | Toyota GR010 - Hybrid | Sébastien Buemi (CHE) | Brendon Hartley (NZL) | Ryo Hirakawa (JPN) |
| 36 | ALPINE ELF TEAM | FRA | Alpine A480 - Gibson | André Negrão (BRA) | Nicolas Lapierre (FRA) | Matthieu Vaxiviere (FRA) |
| 708 | GLICKENHAUS RACING | USA | Glickenhaus 007 LMH | Olivier Pla (FRA) | Romain Dumas (FRA) | Felipe Derani (BRA) |
| 709 | GLICKENHAUS RACING | USA | Glickenhaus 007 LMH | Ryan Briscoe (AUS) | Richard Westbrook (GBR) | Franck Mailleux (FRA) |
| N° | LMP2 | NAT | CAR | Driver #1 | Driver #2 | Driver #3 |
| 1 | RICHARD MILLE RACING TEAM | FRA | Oreca 07 - Gibson | Lilou Wadoux (FRA) | Sébastien Ogier (FRA) | Charles Milesi (FRA) |
| 3 | DKR ENGINEERING | LUX | Oreca 07 - Gibson | Laurents Hörr (DEU)° | Jean Glorieux (BEL)° | Alexandre Cougnaud (FRA) |
| 5 | TEAM PENSKE | USA | Oreca 07 - Gibson | Dane Cameron (USA) | Emmanuel Collard (FRA) | Felipe Nasr (BRA) |
| 9 | PREMA ORLEN TEAM | ITA | Oreca 07 - Gibson | Robert Kubica (POL) | Louis Deletraz (CHE) | Lorenzo Colombo (ITA) |
| 10 | VECTOR SPORT | GBR | Oreca 07 - Gibson | Nico Müller (CHE) | Ryan Cullen (GBR) | Sebastien Bourdais (FRA) |
| 13 | TDS RACING x VAILLANTE | FRA | Oreca 07 - Gibson | Philippe Cimadomo (FRA) | Mathias Beche (CHE)° | Tijmen van der Helm (NLD) |
| 22 | UNITED AUTOSPORTS USA | USA | Oreca 07 - Gibson | Philip Hanson (GBR) | Filipe Albuquerque (PRT) | William Owen (USA) |
| 23 | UNITED AUTOSPORTS USA | USA | Oreca 07 - Gibson | Alexander Lynn (GBR) | Oliver Jarvis (GBR) | Joshua Pierson (USA)° |
| 24 | NIELSEN RACING | GBR | Oreca 07 - Gibson | Rodrigo Sales (USA) | Matt Bell (GBR) | Ben Hanley (GBR) |
| 27 | CD SPORT | ESP | Ligier JSP217 - Gibson | Christophe Cresp (FRA)° | Michael Jensen (DNK) | Sgteven Palette (FRA) |
| 28 | JOTA | GBR | Oreca 07 - Gibson | Oliver Rasmussen (DNK) | Edward Jones (GBR) | Jonathan Aberdein (ZAF) |
| 30 | DUQUEINE TEAM | FRA | Oreca 07 - Gibson | Richard Bradley (GBR)° | Guillermo Rojas (MEX)° | Reshad de Gerus (FRA)° |
| 31 | WRT | BEL | Oreca 07 - Gibson | Sean Gelael (IDN) | Robin Frijns (NLD) | René Rast (DEU) |
| 32 | WRT | BEL | Oreca 07 - Gibson | Rolf Ineichen (CHE) | Mirko Bortolotti (ITA) | Dries Vanthoor (BEL) |
| 34 | INTER EUROPOL COMPETITION | POL | Oreca 07 - Gibson | Jakub Smiechowski (POL) | Alex Brundle (GBR) | Esteban Gutierrez (MEX) |
| 35 | ULTIMATE | FRA | Oreca 07 - Gibson | Jean-Baptiste Lahaye (FRA) | Matthieu Lahaye (FRA) | François Heriau (FRA) |
| 37 | COOL RACING | CHE | Oreca 07 - Gibson | Yifei Ye (CHN)° | Ricky Taylor (USA) | Niklas Kruetten (DEU) |
| 38 | JOTA | GBR | Oreca 07 - Gibson | Roberto Gonzalez (MEX) | Antonio Felix Da Costa (PRT) | William Stevens (GBR) |
| 39 | GRAFF RACING | FRA | Oreca 07 - Gibson | Eric Trouillet (FRA) | Sébastien Page (CHE) | David Droux (CHE) |
| 41 | REALTEAM BY WRT | BEL | Oreca 07 - Gibson | Rui Andrade (PRT) | Ferdinand Habsburg-Lothringen (AUT) | Norman Nato (FRA) |
| 43 | INTER EUROPOL COMPETITION | POL | Oreca 07 - Gibson | David Heinemeier-Hansson (DNK) | Fabio Scherer (CHE) | Pietro Fittipaldi (BRA) |
| 44 | ARC BRATISLAVA | SVK | Oreca 07 - Gibson | Miroslav Konopka (SVK) | Bent Viscaal (NLD) | Tristan Vautier (FRA) |
| 45 | ALGARVE PRO RACING | PRT | Oreca 07 - Gibson | Steven Thomas (USA) | James Allen (AUS) | Rene Binder (AUT) |
| 47 | ALGARVE PRO RACING | PRT | Oreca 07 - Gibson | Sophia Floersch (DEU)° | John Falb (USA) | Jack Aitken (GBR) |
| 48 | IDEC SPORT | FRA | Oreca 07 - Gibson | Paul Lafargue (FRA) | Paul Loup Chatin (FRA) | Patrick Pilet (FRA) |
| 65 | PANIS RACING | FRA | Oreca 07 - Gibson | Julien Canal (FRA) | Nicolas Jamin (FRA) | Job Van Uitert (NLD) |
| 83 | AF CORSE | ITA | Oreca 07 - Gibson | François Perrodo (FRA) | Nicklas Nielsen (DNK) | Alessio Rovera (ITA) |
| N° | LMGTE Pro | NAT | CAR | Driver #1 | Driver #2 | Driver #3 |
| 51 | AF CORSE | ITA | Ferrari 488 GTE EVO | Alessandro Pier Guidi (ITA) | James Calado (GBR) | Daniel Serra BRA) |
| 52 | AF CORSE | ITA | Ferrari 488 GTE EVO | Miguel Molina (ESP) | Antonio Fuoco (ITA) | Davide Rigon (ITA) |
| 63 | CORVETTE RACING | USA | Chevrolet Corvette C8.R | Antonio Garcia (ESP) | Jordan Taylor (USA) | Nicky Catsburg (NLD) |
| 64 | CORVETTE RACING | USA | Chevrolet Corvette C8.R | Tommy Milner (USA) | Nick Tandy (GBR) | Alexander Sims (GBR) |
| 74 | RILEY MOTORSPORTS | USA | Ferrari 488 GTE EVO | Felipe Fraga (BRA) | Sam Bird (GBR) | Shane Van Gisbergen (NZL) |
| 91 | PORSCHE GT TEAM | DEU | Porsche 911 RSR - 19 | Gianmaria Bruni (ITA) | Richard Lietz (AUT) | Frederic Makowiecki (FRA) |
| 92 | PORSCHE GT TEAM | DEU | Porsche 911 RSR - 19 | Michael Christensen (DNK) | Kevin Estre (FRA) | Laurens Vanthoor (BEL) |
| N° | LMGTE Am | NAT | CAR | Driver #1 | Driver #2 | Driver #3 |
| 21 | AF CORSE | ITA | Ferrari 488 GTE EVO | Simon Mann (GBR) | Christoph Ulrich (CHE) | Toni Vilander (FIN) |
| 33 | TF SPORT | GBR | Aston Martin Vantage AMR | Ben Keating (USA) | Henrique Chaves (PRT) | Marco Sorensen (DNK) |
| 46 | TEAM PROJECT 1 | DEU | Porsche 911 RSR - 19 | Matteo Cairoli (ITA) | Mikkel Pedersen (DNK) | Nicolas Leutwiler (CHE) |
| 54 | AF CORSE | ITA | Ferrari 488 GTE EVO | Thomas Flohr (CHE) | Francesco Castellacci (ITA) | Nicholas Cassidy (NZL) |
| 55 | SPIRIT OF RACE | ITA | Ferrari 488 GTE EVO | Duncan Cameron (GBR) | Matthew Griffin (IRL) | David Perel (ZAF) |
| 56 | TEAM PROJECT 1 | DEU | Porsche 911 RSR - 19 | Brendan Iribe (USA) | Olliver Millroy (GBR) | Ben Barnicoat (GBR) |
| 57 | KESSEL RACING | CHE | Ferrari 488 GTE EVO | Takeshi Kimura (JPN) | Frederik Schandorff (DNK) | Mikkel Jensen (DNK) |
| 59 | INCEPTION RACING | GBR | Ferrari 488 GTE EVO | Alexander West (FIN) | Come Ledogar (FRA) | Marvin Kelin (FRA) |
| 60 | IRON LYNX | ITA | Ferrari 488 GTE EVO | Claudio Schiavoni (ITA) | Alessandro Balzan (ITA) | Raffaele Gianmaria (ITA) |
| 61 | AF CORSE | ITA | Ferrari 488 GTE EVO | Louis Prette (ITA) | Conrad Grunewald (USA) | Vincent Abril (FRA) |
| 66 | JMW MOTORSPORT | GBR | Ferrari 488 GTE EVO | Renger Van der Zande (NLD) | Mark Kvamme (USA) | Jason Hart (USA) |
| 71 | SPIRIT OF RACE | ITA | Ferrari 488 GTE EVO | Franck Dezoteux (FRA) | Pierre Ragues (FRA) | Gabriel Aubry (FRA) |
| 75 | IRON LYNX | ITA | Ferrari 488 GTE EVO | Pierre Ehret (DEU) | Christian Hook (BEL) | Nicolas Varrone (ARG) |
| 77 | DEMPSEY-PROTON RACING | DEU | Porsche 911 RSR - 19 | Christian Ried (DEU) | Sebastian Priaulx (FRA) | Harry Tincknell (GBR) |
| 79 | WEATHER TECH RACING | USA | Porsche 911 RSR - 19 | Cooper Mac Neil (USA)° | Julien Andlauer (FRA) | Gianluca Giraudi (ITA) |
| 80 | IRON LYNX | ITA | Ferrari 488 GTE EVO | Matteo Cressoni (ITA) | Giancarlo Fisichella (ITA) | Richard Heistand (USA) |
| 85 | IRON DAMES | ITA | Ferrari 488 GTE EVO | Rahel Frey (CHE) | Michelle Gatting (DNK) | Sarah Bovy (BEL) |
| 86 | GR RACING | GBR | Porsche 911 RSR - 19 | Michael Wainwright (GBR) | Ricardo Pera (ITA) | Benjamin Barker (GBR) |
| 88 | DEMPSEY-PROTON RACING | DEU | Porsche 911 RSR - 19 | Fred Poordad (USA) | Patrick Lindsey (USA) | Jan Heylen (BEL) |
| 93 | PROTON COMPETITION | DEU | Porsche 911 RSR - 19 | Michael Fassbender (IRL) | Matt Campbell (AUS) | Zacharie Robichon (CAN) |
| 98 | NORTHWEST AMR | GBR | Aston Martin Vantage AMR | Paul Dalla Lana (CAN) | David Pittard (GBR) | Nicki Thiim (DNK) |
| 99 | HARDPOINT MOTORSPORT | USA | Porsche 911 RSR - 19 | Rob Ferriol (USA) | Katherine Legge (GBR) | Adrien de Leener (BEL) |
| 777 | D'STATION RACING | JPN | Aston Martin Vantage AMR | Satoshi Hoshino (JPN) | Tomonobu Fujii (JPN) | Charles Fagg (GBR) |
